Evaluation of the Glypican 3 promoter for transcriptional targeting of hepatocellular carcinoma
نویسندگان
چکیده
منابع مشابه
A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma.
Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate worldwide, with limited treatment options. Glypican-3 (GPC3) is a glycosylphosphatidylinositol-anchored glycoprotein that is overexpressed in most HCC tissues but not in normal tissues. GPC3-targeting antibody therapy shows limited response in a clinical trial due to the lack of a tumor-specific cytotoxic T lymphocyte (CTL) ...
متن کاملGlypican-3 as a tumor marker for hepatocellular carcinoma
Article history: Received on: 13/03/2013 Revised on: 04/04/2013 Accepted on: 05/05/2013 Available online: 27/06/2013 Hepatocellular carcinoma(HCC) is one of the most frequent cancers in the world.The burden of HCC has been increasing in Egypt with a doubling in the incidence in the past ten years. The prognosis of most patients is unsatisfactory due to rapid clinical deterioration after the ini...
متن کاملGlypican-3 as a Serum Marker for Hepatocellular Carcinoma
To the Editor: Hippo et al. (1) have recently reported in an article published by Cancer Research that glypican-3 (GPC3) is a serologic marker of hepatocellular carcinoma (HCC). The results published by Hippo et al. basically confirm the findings reported previously by our laboratory (2) and by Nakatsura et al. (3). The fact that three independent laboratories using different anti-GPC3 antibodi...
متن کاملHumanization of high-affinity antibodies targeting glypican-3 in hepatocellular carcinoma
Glypican-3 (GPC3) is a cell-surface heparan sulfate proteoglycan highly expressed in hepatocellular carcinoma (HCC). We have generated a group of high-affinity mouse monoclonal antibodies targeting GPC3. Here, we report the humanization and testing of these antibodies for clinical development. We compared the affinity and cytotoxicity of recombinant immunotoxins containing mouse single-chain va...
متن کاملPrognostic significance of glypican-3 expression in hepatocellular carcinoma
BACKGROUND In recent years, an increasing number of studies has been published analyzing the possible prognostic utility of glypican-3 (GPC3) in hepatocellular carcinoma (HCC), but the results are still controversial. The aim of this meta-analysis was to evaluate possible association between GPC3 expression and patients' survival. METHODS Relevant publications which assessed GPC3 expression w...
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ژورنال
عنوان ژورنال: Gene Therapy
سال: 2018
ISSN: 0969-7128,1476-5462
DOI: 10.1038/s41434-018-0002-2